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Paxil
Generic Name: paroxetine (pa ROX a teen)
Brand Names: Paxil, Paxil CR, Pexeva
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Paxil (paroxetine) is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may become unbalanced.
Paxil is used to treat depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).
Paxil may also be used for purposes not listed in this medication guide.
You should not use Paxil if you are also taking pimozide or thioridazine, or if you are being treated with methylene blue injection. Do not start or stop taking this medicine during pregnancy without your doctor's advice.
Do not use an MAO inhibitor within 14 days before or after you take Paxil. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Paxil. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Do not give Paxil to anyone younger than 18 years old without the advice of a doctor. Paxil is not approved for use in children.
You should not use Paxil if you are allergic to paroxetine, or if:
you are also taking pimozide or thioridazine; or
you are being treated with methylene blue injection.
Do not use an MAO inhibitor within 14 days before or after you take Paxil. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking Paxil you must wait at least 14 days before you start taking an MAO inhibitor.
To make sure Paxil is safe for you, tell your doctor if you have:
liver or kidney disease;
a bleeding or blood clotting disorder;
seizures or epilepsy;
bipolar disorder (manic depression), or a history of drug abuse or suicidal thoughts;
narrow-angle glaucoma; or
if you take warfarin (Coumadin) to prevent blood clots.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Paxil. Your family or other caregivers should also be alert to changes in your mood or symptoms.
FDA pregnancy category D. Taking an SSRI antidepressant during pregnancy may cause heart defects, serious lung problems, or other complications in the baby. However, you may have withdrawal symptoms or a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant while taking Paxil. Do not start or stop taking this medicine during pregnancy without your doctor's advice.
See also: Pregnancy and breastfeeding warnings (in more detail)
Paroxetine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Do not give Paxil to anyone younger than 18 years old without the advice of a doctor. Paxil is not approved for treating depression in children.
Take Paxil exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Do not stop using Paxil suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Paxil. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture, heat, and light.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at . An overdose of paroxetine can be fatal.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with Paxil may cause you to bruise or bleed easily.
Drinking alcohol can increase some of the side effects of Paxil.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Get emergency medical help if you have any of these signs of an allergic reaction to Paxil: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
unusual bone pain or tenderness, swelling or bruising;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), coughing up blood;
high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, loss of coordination, feeling unsteady;
severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Paxil side effects may include:
mild headache, drowsiness, dizziness, tired feeling;
sleep problems (insomnia), feeling restless or nervous;
mild nausea, constipation, weight changes;
decreased sex drive, impotence, or difficulty having an orgasm; or
dry mouth, yawning, or ringing in your ears.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at .
See also: Side effects (in more detail)
Taking Paxil with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking Paxil with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety or seizures.
Many drugs can interact with paroxetine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Paxil, especially:
any other antidepressant;
tamoxifen;
tramadol;
tryptophan (sometimes called L-tryptophan); or
medicine to treat mental illness--lithium, thioridazine, and others.
This list is not complete and many other drugs can interact with Paxil. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
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