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Actoplus Met contains a combination of metformin and pioglitazone, two oral diabetes medicines that help control blood sugar levels.
Actoplus Met is used in patients with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes.
Actoplus Met may also be used for purposes not listed in this medication guide.
You should not use Actoplus Met if you have severe or uncontrolled heart failure, kidney problems, metabolic acidosis, or if you have bladder cancer. Do not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Actoplus Met is not for treating type 1 diabetes.
Actoplus Met can cause or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Actoplus Met.
Some people develop lactic acidosis while taking metformin. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.
Do not use Actoplus Met if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
You should not use Actoplus Met if you are allergic to metformin or pioglitazone, or if you have:
severe or uncontrolled heart failure;
active bladder cancer; or
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Actoplus Met. Be sure your caregivers know ahead of time that you are using this medication.
Some people taking metformin develop a serious condition called lactic acidosis. This may be more likely if you have liver or kidney disease, congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your risk.
To make sure Actoplus Met is safe for you, tell your doctor if you have:
congestive heart failure or heart disease;
a history of bladder cancer;
a history of heart attack or stroke;
liver disease; or
if you are 80 years or older.
Taking Actoplus Met may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with Actoplus Met.
This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.
Women may be more likely than men to have bone fractures in the upper arm, hand, or foot while taking medicine that contains pioglitazone. Talk with your doctor if you are concerned about this possibility.
FDA pregnancy category C. It is not known whether Actoplus Met will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
See also: Pregnancy and breastfeeding warnings (in more detail)
Some women using Actoplus Met have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.
It is not known whether metformin or pioglitazone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Actoplus Met.
Take Actoplus Met exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take Actoplus Met with meals. Take the extended-release Actoplus Met XR tablet once daily with your evening meal.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.
If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.
Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.
Use Actoplus Met regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
If you take extra vitamin B12 while you are taking Actoplus Met, take only the amount of vitamin B12 that your doctor has prescribed.
Actoplus Met is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
Take the missed dose as soon as you remember (be sure to take the medicine with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at .
Avoid drinking alcohol. It can lower your blood sugar and may increase your risk of lactic acidosis.
Some people develop lactic acidosis while taking metformin. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.
Get emergency medical help if you have any of these signs of an allergic reaction to Actoplus Met: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
shortness of breath (even with mild exertion), swelling, rapid weight gain;
pink or red urine, painful or difficult urination, urinating more than usual;
pale skin, easy bruising or bleeding;
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
changes in your vision.
Common Actoplus Met side effects may include:
cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at .
See also: Side effects (in more detail)
Tell your doctor if you use insulin. Taking Actoplus Met while you are using insulin may increase your risk of serious heart problems.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Actoplus Met, especially:
an antibiotic--rifampin, trimethoprim, vancomycin; or
heart or blood pressure medication--digoxin, nifedipine, procainamide, quinidine.
You may be more likely to have hyperglycemia (high blood sugar) if you also take other drugs that can raise blood sugar, such as:
diuretics (water pills);
steroids (prednisone and others);
niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones; and
diet pills or medicines to treat asthma, colds or allergies.
These lists are not complete and many other medicines can increase or decrease the effects of Actoplus Met on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
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